CD3e (T-Cell Marker)(OKT3) , Biotin conjugate , 0.1mg / mL

Recognizes the epsilon-chain of CD3 , which consists of five different polypeptide chains (designated as gamma , delta , epsilon , zeta , and eta) with MW ranging from 16-28 kDa. CD3 , also known as T3 , is a member of the immunoglobulin superfamily that plays a role in antigen recognition , signal transduction , and T cell activation. It is found on all mature T-lymphocytes , NK , T-cells , and some thymocytes , and is expressed , typically at high levels , on peripheral T cells and majority of T cell neoplasms. Thymocytes express CD3 at different level on the cell surface in the course of differentiation and CD3 is predominantly intracytoplasmic in cortical thymus._x000D_ _x000D_ Anti-CD3 clone OKT3 has been reported to have potent immunosuppressive properties in vivo and has been proven effective in the treatment of renal , heart and liver allograft rejection. In the crystal structure of the antibody-receptor complex , clone OKT3 was found to bind a conformational epitope on CD3e dominated by a linear stretch in the F-G loop of the subunit._x000D_ _x000D_ Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors._x000D_ _x000D_