c-Myb(MYB286) , Biotin conjugate , 0.1mg / mL

The highly leukemogenic avian retrovirus E26 contains two oncogenes , v-Myb and v-Ets , which are expressed together as a fusion protein. The cellular homolog of v-Myb , designated c-Myb , encodes a transcription factor. Deletion or disruption of a negative regulatory domain mapping within the carboxy-terminal domain of c-Myb results in enhanced transactivating capacity and in parallel , leads to activation of its ability to transform hemopoietic cells. c-Myb is expressed preferentially , but not exclusively , in immature hemopoietic cells and its expression decreases as cells differentiate.Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.