CD1b(RIV12) , Biotin conjugate , 0.1mg / mL

The mouse monoclonal antibody recognizes CD1b , a 44 kDa type I glycoprotein associated with beta2-microglobulin. It is expressed on dendritic cells , Langerhans cells , thymocytes , and T acute lymphoblastic leukemia cells. The CD1 multigene family encodes five forms of the CD1 T-cell surface glycoprotein in human , designated CD1A , 1B , 1C , 1D and 1E. CD1 , a type 1 membrane protein , has structural similarity to the MHC class I antigen and has been shown to present lipid antigens for recognition by T lymphocytes. Constitutive endocytosis of CD1B molecules and the differential sorting of MHC class II from lysosomes separate peptide- and lipid antigen-presenting molecules during dendritic cell maturation. CD1B is also expressed in interdigitating cells.Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.