VEGFR2 / Flk-1 / KDR3 / CD309(KDR657) , Biotin conjugate , 0.1mg / mL

CD309 , also known as VEGF-R2 , KDR3 , and Flk-1 (mouse) , is a type I transmembrane glycoprotein. It is a member of the CSF-1/PDGF receptor family of type III tyrosine kinase receptors. Human VEGF-R2 is mainly expressed by endothelial cells , embryonic tissues , and megakaryocytes. It plays an important role in the regulation of angiogenesis , vasculogenesis , and vascular permeability. The ligands of VEGF-R2 include VEGF-A , VEGF-C , VEGF-D , and VEGF splice isoforms. Ligation of VEGF-R2 with its ligands results in the receptor dimerization and auto-phosphorylation , stimulating endothelial cell proliferation and migration.Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.