Cytokeratin 7/17(C-46) , Biotin conjugate , 0.1mg / mL

Recognizes intermediate filament proteins (IFP's) of 55 kDa and 46 kDa , which are identified as cytokeratin 7 and Cytokeratin 17 respectively. On formalin-fixed , paraffin embedded sections , C-46 reacts with keratin 7 only. Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. Cytokeratins have been found to be useful markers of tissue differentiation , which is directly applicable to the characterization of malignant tumors. Cytokeratin 7 is a basic cytokeratin , which is found in most glandular and transitional epithelia but not in the stratified squamous epithelia. Cytokeratin 7 is expressed in the epithelial cells of ovary , lung , and breast but not of colon , prostate , or gastrointestinal tract. Cytokeratin 17 is expressed in epithelial cells of various origins , such as bronchial epithelial cells and skin appendages. Cytokeratin 17 antibody marks basal cell differentiation._x000D_ _x000D_ Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors._x000D_ _x000D_