CD74(CLIP/1133) , Biotin conjugate , 0.1mg / mL

Recognizes proteins of 33 , 35 and 41 kDa , which are identified as various isoforms of CD74. Its epitope is localized in the extracellular domain of CD74. CD74 is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. The CD74 molecule plays a critical role in the presentation of peptides , by the MHC class II antigens , to CD4 positive lymphocytes. CD74 is expressed on MHC class II positive cells including B cells , a subset of activated T cells , monocytes , and dendritic cells and by various types of carcinomas. CD74 is expressed primarily by antigen presenting cells , such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage) , macrophages , and monocytes , and many epithelial cells. Anti-CD74 stains predominantly germinal center lymphocytes and B-cell lymphomas , but rarely T-cell lymphomas. Anti-CD74 has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma ( ).Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.