IDH1(IDH1/1152) , Biotin conjugate , 0.1mg / mL

This antibody recognizes a 45 kDa protein , which is identified as isocitrate dehydrogenase (IDH1). It belongs to the isocitrate and isopropylmalate dehydrogenases family. IDH1 catalyzes the third step of the citric acid cycle , which involves the oxidative decarboxylation of isocitrate , forming alpha-ketoglutarate and CO2 in a two-step reaction. The first step involves the oxidation of isocitrate to the intermediate oxalosuccinate , while the second step involves the production of alpha-ketoglutarate. During this process , either NADH or NADPH is produced along with CO2. Recently , an inactivating mutation of IDH1 has been implicated in glioblastoma. IDH1 appears to function as a tumor suppressor that , when mutationally inactivated , contributes to tumorigenesis in part through induction of the HIF-1 pathway._x000D__x000D_Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.