STAT6 (Solitary Fibrous Tumor Marker)(STAT6/2410) , Biotin conjugate , 0.1mg / mL

STAT6 is a transcription factor in the Jak/STAT signal transduction pathway responsible for mediating IL-4 immune signaling. STAT6 was recently suggested to be a reliable marker to distinguish solitary fibrous tumors from other soft tissue neoplasms. Gene fusions are common in solitary fibrous tumors. Recent next generation sequencing studies demonstrated the presence of a NAB2-STAT6 fusion , formed by an intrachromosomal inversion fusing two neighboring genes on chromosome 12q13 , in 55-100% of solitary fibrous tumors , regardless of tumor morphology or anatomical site. By immunohistochemistry , nuclear STAT6 expression can discriminate solitary fibrous tumors from its morphological mimics in the meninges , including meningioma , glioblastoma , gliosarcoma , haemangioblastoma , schwannoma and haemangioma. A recent study by Cheah , et al. using the rabbit monoclonal STAT6 antibody (Clone YE361) observed expression in all solitary fibrous tumors (54/54) tested , regardless of histology , anatomical site or CD34 status. Morphological mimics of solitary fibrous tumors were negative , demonstrating 100% specificity._x000D_ _x000D_ Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors._x000D_ _x000D_