BOB.1 (B-Cell Marker)(BOB1/2422) , Biotin conjugate , 0.1mg / mL

BOB-1 is a transcriptional coactivator that specifically associates with either POU2F1/OCT1 or POU2F2/OCT2 , boosting the promoter activity of those complexes. It is essential for the response of B-cells to antigens , required for the formation of germinal centers , and regilates IL-6 expression. BOB-1 expression in a variety of established B-cell lines , representing different stages of B-cell development , has suggested a constitutive , B-cell-specific expression pattern. LP cells in nodular lymphocyte predominant Hodgkin lymphoma , because they are germinal center-derived , are consistently immuno-positive for BOB-1. Conversely , only some cases of classical Hodgkin lymphoma show BOB-1 immuno-reactivity within the Hodgkin and Reed-Sternberg cells. Expression of BOB-1 has been reported in follicular center cell lymphoma , diffuse large B-cell lymphoma and some cases of acute myeloid leukemia. B-CLL , marginal zone lymphoma , and mantle cell lymphoma may show weak to moderate immunoreactivity. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.