NKX6.1 (Marker for Pancreatic and Duodenal Neuroendocrine Tumors) (NKX61/2561) , Biotin conjugate , 0.1mg / mL

Members of the Nkx family of homeodomain proteins are key regulators of growth and development in several tissues , including brain , heart and pancreas. During neural development , sonic hedgehog (Shh) is known to control cell fate and mitogenesis , which is correlated with Shh dose-dependent expression of several genes , including Nkx-6.1. Specifically , Nkx-6.1 is responsible for cellular differentiation in the ventral neural tube and spinal meninges in response to Shh. In the pancreas , Nkx-6.1 is exclusively expressed in the islets of Langerhans in differentiating and mature B cells , which produce Insulin. The presence of Pdx-1 is required for the expression of Nkx-6.1 as well as other pancreatic B cell specific genes , including Insulin , Glut2 and IAPP. Subsequently , Nkx-6.1 binds to the DNA consensus sequence , TTAATTAC , to direct the repression of specific genes in B cells.Nkx6.1 is highly expressed in pancreatic and duodenal well-differentiated neuroendocrine tumors (WDNETS) and in metastatic WDNETS , is a highly specific marker of tumors of pancreatic origin. It has thus been suggested that Nkx6.1 is a useful inclusion into IHC panels for identifying primary sites of WDNETS.Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.