n-Myc (Neuroblastoma Marker)(NMYC-1) , Biotin conjugate , 0.1mg / mL

The v-Myc oncogene , initially identified in the MC29 avian retrovirus , causes myelocytomas , carcinomas , sarcomas and lymphomas , and belongs to a family of oncogenes conserved throughout evolution. In humans , the family consists of five genes: c-Myc , N-Myc , R-Myc , L-Myc and B-Myc. Amplification of the N-Myc gene has been found in human neuroblastomas and cell lines. Its amplification correlates well with the stage of neuroblastoma disease. Immunological studies have shown that the human N-Myc gene encodes a nuclear phosphoprotein that exhibits relatively short (30 min) half life in vivo. The prototype member of the family , c-Myc p67 , binds DNA in a sequence-specific manner subsequent to dimerization with a second basic region helix-loop-helix leucine zipper motif protein , designated Max. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.