IgD (Immunoglobulin Delta Heavy Chain) (B-Cell Marker) (IGHD/2730R) , Biotin conjugate , 0.1mg / mL

Immunoglobulins are four-chain , Y-shaped , monomeric structures comprised of two identical heavy chains and two identical light chains held together through interchain disulfide bonds. The chains form two domains , the Fab (antigen binding) fragment and the Fc (constant) fragment. Immunoglobulin D (IgD) exists as a monomer withδ heavy chains and either κ or λ light chains. It plays a biological role as a transmembrane receptor molecule , co-expressed with IgM on the surface of mature/naive B cells. In particular , it is found on spleen B cell surfaces. Compared to IgM , IgD exists in much lower numbers and is not expressed on immature B cells. IgD surface expression on B cells is regulated in part by IL-27. In mice , the inhibition of this immunoglobulin isotype does not cause a significant change to the immune system._x000D_ _x000D_ Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors._x000D_ _x000D_