DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker)(DG1/2831R) , Biotin conjugate , 0.1mg / mL

Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GIST's) , c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors , which , due to appearance , may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97. 8 percent of scorable GIST's , including all c-kit negative GIST's. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs , including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GIST's is nearly identical: 94. 4% vs. 94. 7%. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.