Complement 3d (C3d) (Acute Humoral Rejection Marker)(C3D/2891) , Biotin conjugate , 0.1mg / mL

The complement component proteins , C2 , C3 , C4 and C5 , are potent anaphylatoxins that are released during complement activation. Binding of these proteins to their respective G protein-coupled receptors , C3aR , C1R and C5aR , induces proinflammatory events , such as cellular degranulation , smooth muscle contraction , arachidonic acid metabolism , cytokine release , leukocyte activation and cellular chemotaxis. C3d is a terminal degradation product of C3 that plays an important role in modulation of the adaptive immune response through the interaction with complement receptor type 2 (CR2). CR2 is important in the switched-isotype , high-affinity and memory humoral immune responses to T-dependent foreign antigens , as well as in the development of the natural antibody repertoire. This pH- and ionic strength-dependent association of C3d with CR2 represents a link between innate and adaptive immunity. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.