ICOS-L / ICOS Ligand / B7RP-1 (Immuno-Oncology Target)(ICOSL/3111) , Biotin conjugate , 0.1mg / mL

This MAb recognizes a protein of 36 kDa , identified as ICOS-L. It is a ligand for the ICOS receptor that initiates T and B cell proliferation and cytokine secretion. ICOS-L interactions play an essential role in T cell-dependent B cell activation in peripheral lymphoid organs such as spleen and lymph nodes. ICOS-L protein is present in myeloid leukocytes , and by Northern blot there are 2. 4 , 3. 0 , and 7. 0 kb transcripts in brain , heart , kidney , and liver , with lower expression in colon and thymus , and a 1. 1 kb transcript in leukocytes. Tumor necrosis factor alpha (TNF) , granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4) enhance its expression. LPS-induced up-regulation of ICOS-L is dependent on the MyD88-dependent signaling pathway. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.