Replication Protein A2 (RPA2)(RPA2/3140R) , Biotin conjugate , 0.1mg / mL

Recognizes a protein of 34 kDa , identified as a subunit of Replication Protein A (RPA) (also known as human single-stranded DNA binding protein , or HSSB). RPA from human cells is a stable heterotrimer of 70 kDa , 32-34 kDa , and 11-14 kDa subunits (RPA70 , RPA32 , and RPA14 respectively). It is involved in DNA replication , repair , and recombination. RPA is required for the SV40 large tumor antigen-catalyzed unwinding of SV40 DNA and stimulates DNA polymerase (pol) alpha and delta. RPA34 is phosphorylated at the G1/S boundary of the cell cycle or upon exposure of cells to DNA damage-inducing agents including ionizing and UV radiation. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.