Calbindin 1 (CALB1)(CALB1/3333) , Biotin conjugate , 0.1mg / mL

Calbindin 1 , also known as calbindin D28K , is a member of a family of calcium binding proteins. This protein family also includes calmodulin , calbindin 2 , S-100 , and troponin C. Calbindin 1 is a 261-amino acid protein with 6 EF-hand domains , 4 of which are active calcium-binding domains. Expressed in brain , ovary , uterus , testis , pancreas , liver , kidney and intestine , calbindin 1 acts as a calcium-buffering agent and alters the activity of the plasma membrane ATPase. In neuronal cells , calbindin 1 modulates calcium channel activity , calcium transients and intrinsic neuronal firing activity. Also , calbindin 1 has been implicated to play a role in apoptosis and microtubule function. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.