CD81 / TAPA-1 (rC81/3442) , Biotin conjugate , 0.1mg / mL

This antibody recognizes a protein of 26 kDa , identified as CD81 (Workshop VI; Code CD81.1)). CD81 has a very broad cellular distribution , being expressed on T- and B-lymphocytes , NK cells , thymocytes , eosinophils , fibroblasts , epithelial and endothelial cells. Neutrophils , erythrocytes and platelets are negative , while monocytes are variably positive. CD81 is a member of a family of tetraspanin transmembrane proteins , including CD9 , CD37 , CD53 , CD63 , and CD82. It associates with CD19 , CD21 , Leu 13 , and integrins on cell membrane and is involved in signal transduction in B lymphocyte development and cell adhesion. CD81 also acts as a receptor for the envelope protein E2 of chronic hepatitis C virus. Antibodies to CD81 have anti-proliferative effects on different lymphoid cell lines , particularly those derived from large cell lymphomas._x000D_ _x000D_ Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors._x000D_ _x000D_