SOX2 (Embryonic Stem Cell Marker)(rSOX2/1791) , Biotin conjugate , 0.1mg / mL

SOX2 is required for stem cell maintenance in the central nervous system , and it also regulates gene expression in the stomach. SOX2 is necessary for regulating multiple transcription factors that affect Oct 3/4 expression. An essential function of SOX2 is to stabilize embryonic stem cells in a pluripotent state by maintaining the requisite level of Oct 3/4 expression. Reportedly , SOX2 is associated with aggressive phenotypes of breast , head and neck , gastric , colorectal , bladder , and small cell lung cancers. However , SOX2 is expressed in a high percentage of lung squamous cell carcinomas and has been shown to be an independent favorable prognostic marker. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.