Endophilin I rabbit pAb - 100 μL

Domain: An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes. The BAR domain dimer forms a rigid crescent shaped bundle of helices with the pair of second amphipathic helices protruding towards the membrane-binding surface. function: Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. miscellaneous: HeLa cells expressing the N-BAR domain of SH3GL2 show tubulation of the plasma membrane. The N-BAR domain binds liposomes and induces formation of tubules from liposomes. The N-terminal amphipathic helix is required for liposome binding. The second amphipathic helix enhances liposome tubulation. similarity: Belongs to the endophilin family. similarity: Contains 1 BAR domain. similarity: Contains 1 SH3 domain. subcellular location: Concentrated in presynaptic nerve terminals in neurons. subunit: Monomer; in cytoplasm. Homodimer; when associated with membranes (By similarity). Interacts with SYNJ1 and DNM1. Interacts with MAP4K3; the interaction appears to regulate MAP4K3-mediated JNK activation. Interacts with PDCD6IP. tissue specificity: Brain, mostly in frontal cortex. Expressed at high level in fetal cerebellum.