CD53(63-5A3) , Biotin conjugate , 0.1mg / mL

Recognizes a protein of 33-55 kDa , identified as CD53 (Workshop V; Code CD53.1). CD53 is expressed on monocytes , and macrophages , granulocytes , dendritic cells , osteoblasts and osteoclasts , NK cells , and on T- and B-cells from every stage of differentiation but is absent from platelets , erythrocytes , and non-haemopoietic cells. CD53 is a member of a family of tetraspan transmembrane proteins , including CD9 , CD37 , CD63 , CD81 , and CD82. It associates with integrins , MHC class II molecules , and a tyrosine phosphatase and plays a role in cellular activation as part of a signal transduction complex involving other membrane glycoproteins. Defects of CD53 expression on neutrophils appear to be related with recurrent infectious diseases. Cross-linking CD53 using CD53 antibodies led to cytoplasmic calcium fluxes in B cells , monocytes , and granulocytes and activation of the monocyte oxidative burst.Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.