HSP27 (Heat Shock Protein 27) (rHSPB1/774) , Biotin conjugate , 0.1mg / mL

MAb rHSPB1/774 reacts specifically with heat shock protein HSP27 in human and monkey tissues and cell lines such as MCF-7. HSP27 , also referred to as the Estrogen-Regulated 24K protein and HSP28 , is one of several small heat shock proteins produced by all organisms studied. HSP27 synthesis is induced by elevated temperature , as well as by estrogen in hormone responsive cells. Interestingly , human HSP27 also shares greater than 50% homology with low molecular weight Drosophila HSPs and mammalian alpha-crystalline lens protein. Because of the estrogen responsive nature of HSP27 , this protein has been studied extensively in human estrogen responsive tissues such as cervix , endometrium and breast tissue. Therefore HSP27 may be useful in classifying various hormone sensitive tumorsPrimary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.