Thrombomodulin / CD141 (Endothelial Cell Marker) (rTHBD/1591) , Biotin conjugate , 0.1mg / mL

This antibody recognizes a protein of 75 kDa , identified as Thrombomodulin. Thrombomodulin is a transmembrane glycoprotein with natural anticoagulant properties. It is normally expressed by a restricted number of cells , such as endothelial and mesothelial cells. In addition , synovial lining and syncytio-trophoblasts of placenta also express thrombomodulin. This protein is present in almost all of benign vascular tumors and majority of malignant vascular tumors (Kaposi's sarcoma , angiosarcoma , and epithelioid hemangioendothelioma). Hence , anti-thrombomodulin serves as a sensitive marker for lymphatic endothelial cells and their tumors. Recently , thrombomodulin antibody has been used for mesothelial cells and malignant mesotheliomas.Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.