SDHB (Succinate Dehydrogenase B) (Pheochromocytoma Marker)(SDHB/2382) , Biotin conjugate , 0.1mg / mL

Succinate dehydrogenase (SDH) is Complex II in the mitochondria , vital for mitochondrial electron transport , as well as Krebs cycle function. Four subunits comprise the SDH protein complex: a flavochrome subunit (SDHA) , an iron-sulfur protein (SDHB) and two membrane-bound subunits (SDHC and SDHD) anchored to the inner mitochondrial membrane. The SDH complex functions as a tumor suppressor. Loss of any subunit proteins lead to destabilization of the complex and tumor formation. Antibody to SDHB is helpful in the identification of phaeochromocytomas , paragangliomas and GIST. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.