OLIG2 (Marker of Glial Brain Tumors) (OLIG2/2400) , Biotin conjugate , 0.1mg / mL

Olig2 , a basic helix-loop-helix transcription factor , is involved in oligodendroglial specification. Olig2 expression has been reported in most glial tumors , such as oligodendrogliomas and astrocytomas. Although more than half of glioblastomas are positive for Olig2 , expression is very weak in terms of both percentage of labeled cells and intensity. No Olig2 expression has been found in the non-glial tumors including neuro-epithelial tumors , ependymomas , sub-ependymomas , medulloblastomas , and non-neuroepithelial tumors , such as CNS lymphomas , meningiomas , schwannomas , atypical teratoid / rhabdoid tumor , and haemangioblastomas. Compared to the strong staining seen in glioma samples , a weak expression is observed in non-tumoral brain tissue (gliosis).Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.