SMAD4 (Pancreatic Adenocarcinoma Marker)(SMAD4/2524) , Biotin conjugate , 0.1mg / mL

Signaling from the ligand-activated membrane receptor serine/threonine kinases to nuclear targets is mediated by a set of evolutionarily conserved proteins known as DPC4. Upon ligand binding , the receptors of the TGF- family phosphorylate SMAD proteins (SMAD1 and SMAD2). These proteins then move into the nucleus , where they activate transcription. To carry out this function , the receptor activated SMAD1 and 2 require association with the product of deleted in pancreatic carcinoma , locus 4 (DPC4) , also known as SMAD4. SMAD4/DPC4 is also implicated as a tumor suppressor , since it is inactivated in more than half of pancreatic carcinomas and to a lesser extent in a variety of other cancers. SMAD4 is absent in approximately 80% of pancreatic adenocarcinoma , but rarely in endometrial , colorectal , ovarian , lung , breast adenocarcinomas , and malignant melanom. SMAD4 is an important marker for confirming a diagnosis of pancreatic adenocarcinoma. Patients with pancreatic adenocarcinomas with SMAD4 protein expression had significantly longer survival than SMAD4 negative patients. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.