Spastin(Sp 3G11-1) , Biotin conjugate , 0.1mg / mL

The AAA protein family members share an ATPase domain and have roles in various cellular processes including intracellular motility , membrane trafficking , proteolysis , protein folding and organelle biogenesis. Spastin , a member of the AAA protein family , is a 616 amino acid protein and is involved in the function or assembly of nuclear protein complexes. The Spastin protein is expressed ubiquitously and localizes to the nucleus and the cytoplasm , where it may also be involved in microtubule dynamics. Mutations in the Spastin gene (SPAST , SPG4) cause the most common form of spastic paraplegia 4 , an autosomal dominant form of hereditary spastic paraplegia (HSP). HSPs comprise a group of inherited neurological disorders characterized by spastic lower extremity weakness due to a length-dependent , retrograde axonopathy of corticospinal motor neurons. SPAST-specific mutations account for approximately 40% of all autosomal dominant HSPs. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.