Lymphocyte Specific Protein 1 (LSP1) / pp52(LSP1/3025) , Biotin conjugate , 0.1mg / mL

LSP1 is a hematopoietic-expressed gene that encodes an F-actin-binding , leukocyte-specific (including B and T lymphocytes , granulocytes and macrophages) , phosphoprotein. However , mRNA splice variants that do not encode the lympho-specific protein are expressed from this gene in nonlymphoid cell lines as well (myocytes , stromal cells and fibroblasts) , suggesting pp52 has a divergent role in signal transduction. The pp52 (LSP1) locus maps to human chromosome 11p15. 5 , which is implicated in tumor-related chromosomal translocations found in chronic lymphocytic leukemia. The pp52 promoter contains key elements that control transcriptional activity including an initiator specifying the unique 5' terminus of pp52 mRNA , tandem pairs of Ets and SP1 motifs , and a single C/EBP motif. LSP1 binds the cytoskeleton and has been implicated in affecting cytoskeletal remodeling in a variety of leukocyte functions , including cell motility and chemotaxis. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.