Serum Amyloid P / APCS(APCS/3240) , Biotin conjugate , 0.1mg / mL

Serum amyloid P (SAP) is a glycoprotein belonging to the pentraxin family of proteins , which has a characteristic pentameric organization and calciumdependent ligand binding. Secreted by liver epithelial cells , SAP is found in serum and urine. Although the function of SAP has not been clearly established , it has been shown to interact with DNA and histones and is thought to play a role in scavenging nuclear material released from damaged circulating cells. Also designated PTX2 , SAP is a precursor of the protein amyloid P component (AP) , which is universally associated with the amyloid deposits in all forms of amyloidoses , including Alzheimer's disease. SAP is a decamer of ten identical , noncovalently linked subunits , each of which may be post-translationally modified by glycosylation. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.