Cytokeratin 5 (KRT5) (Basal , Myoepithelial & Mesothelial Cell Marker)(KRT5/3594) , Biotin conjugate , 0.1mg / mL

This MAb recognizes a protein of 58 kDa , which is identified as Cytokeratin 5 (KRT5). This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Antibodies to KRT5 identify basal cells of squamous and glandular epithelia , myoepithelia , and mesothelium. Anti-cytokeratin 5 has been reported useful in the differential diagnosis of metastatic carcinoma in the pleura versus epithelioid mesothelioma. Almost all squamous cell carcinomas , half of transitional carcinomas , and many undifferentiated large cell carcinomas express. Anti-KRT5 , along with anti-p63 , affords a high sensitivity and specificity for squamous differentiation. Myoepithelial cells of the breast , glandular epithelia , and basal cells of the prostate are labeled with anti-KRT5. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.