Volume : 50 µg
Clone Number :
Aliases : G alpha 12 antibody; G alpha-12 antibody; G-protein subunit alpha-12 antibody; gep antibody; Gna12 antibody; GNA12_HUMAN antibody; guanine nucleotide binding protein (G protein) alpha 12 antibody; Guanine nucleotide binding protein alpha 12 subunit antibody; Guanine nucleotide-binding protein subunit alpha-12 antibody; MGC104623 antibody; MGC99644 antibody; NNX3 antibody; RMP antibody; W µgSC : H_GS165O14.2 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q03113
Immunogen : Recombinant Human Guanine nucleotide-binding protein subunit alpha-12 protein (112-270AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Guanine nucleotide-binding proteins (G proteins) are involved as mod µLators or transducers in various transmembrane signaling systems (PubMed : 22609986, PubMed : 15525651 PubMed : 15240885, PubMed : 17565996, PubMed : 12515866, PubMed : 16787920, PubMed : 16705036, PubMed : 23762476, PubMed : 27084452). Activates effector molec µLe RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (PubMed : 15240885, PubMed : 12515866, PubMed : 16202387). GNA12-dependent Rho signaling subsequently reg µLates transcription factor AP-1 (activating protein-1) (By similarity). GNA12-dependent Rho signaling also reg µLates protein phosphatese 2A activation causing dephosphorylation of its target proteins (PubMed : 15525651 PubMed : 17565996). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-reg µLating proinflammatory cytokine production (PubMed : 23762476, PubMed : 16787920, PubMed : 16705036, PubMed : 27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed : 11976333, PubMed : 16787920). Together with NAPA promotes CDH5 localization to plasma membrane (PubMed : 15980433). May play a role in the control of cell migration thro µgh the TOR signaling cascade (PubMed : 22609986).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : GNA12
Research Areas : Signal transduction