Csk rabbit pAb - 50 μL

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. function: Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases. PTM: Autophosphorylation of Tyr-304 occurs only at abnormally high CSK concentrations in vitro. similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily. similarity: Contains 1 protein kinase domain. similarity: Contains 1 SH2 domain. similarity: Contains 1 SH3 domain. subcellular location: Mainly cytoplasmic, also present in lipid rafts. subunit: Interacts with PTPN8 (By similarity). Interacts with phosphorylated SIT1, PAG1, LIME1 and TGFB1I1. tissue specificity: Expressed in lung and macrophages.