Volume : 50 µg
Clone Number :
Aliases : HRG antibody; Histidine-rich glycoprotein antibody; Histidine-proline-rich glycoprotein antibody; HPRG antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P04196
Immunogen : Recombinant Human Histidine-rich glycoprotein protein (412-511AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan s µLfate, thrombospondin, plasminogen, and divalent metal ions. Binds heparin and heparin/glycosaminoglycans in a zinc-dependent manner. Binds heparan s µLfate on the surface of liver, lung, kidney and heart endothelial cells. Binds to N-s µLfated polysaccharide chains on the surface of liver endothelial cells. Inhibits rosette formation. Acts as an adapter protein and is implicated in reg µLating many processes such as immune complex and pathogen clearance, cell chemotaxis, cell adhesion, angiogenesis, coag µLation and fibrinolysis. Mediates clearance of necrotic cells thro µgh enhancing the phagocytosis of necrotic cells in a heparan s µLfate-dependent pathway. This process can be reg µLated by the presence of certain HRG ligands such as heparin and zinc ions. Binds to IgG subclasses of immunoglobins containing kappa and lambda light chains with different affinities reg µLating their clearance and inhibiting the formation of insoluble immune complexes. Tethers plasminogen to the cell surface. Binds T-cells and alters the cell morphology. Mod µLates angiogenesis by blocking the CD6-mediated antiangiongenic effect of thrombospondins, THBS1 and THBS2. Acts as a reg µLator of the vasc µLar endothelial growth factor (VEGF) signaling pathway; inhibits endothelial cell motility by reducing VEGF-induced complex formation between PXN/paxillin and ILK/integrin-linked protein kinase and by promoting inhibition of VEGF-induced tyrosine phosphorylation of focal adhesion kinases and alpha-actinins in endothelial cells. Also plays a role in the reg µLation of tumor angiogenesis and tumor immune surveillance. Normalizes tumor vessels and promotes antitumor immunity by polarizing tumor-associated macrophages, leading to decreased tumor growth and metastasis.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : HRG
Research Areas : Cardiovasc µLar